Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Loss of MPC1 reprograms retinal metabolism to impair visual function.

Grenell, Allison; Wang, Yekai; Yam, Michelle; Swarup, Aditi; Dilan, Tanya L; Hauer, Allison; Linton, Jonathan D; Philp, Nancy J; Gregor, Elizabeth; Zhu, Siyan; Shi, Quan; Murphy, Joseph; Guan, Tongju; Lohner, Daniel; Kolandaivelu, Saravanan; Ramamurthy, Visvanathan; Goldberg, Andrew F X; Hurley, James B; Du, Jianhai.

Proc Natl Acad Sci U S A ; 116(9): 3530-3535, 2019 02 26.

Artigo em Inglês | MEDLINE | ID: mdl-30808746

2.

Impact of euthanasia, dissection and postmortem delay on metabolic profile in mouse retina and RPE/choroid.

Zhu, Siyan; Yam, Michelle; Wang, Yekai; Linton, Jonathan D; Grenell, Allison; Hurley, James B; Du, Jianhai.

Exp Eye Res ; 174: 113-120, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29864440

3.

How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration.

Du, Jianhai; An, Jie; Linton, Jonathan D; Wang, Yekai; Hurley, James B.

Adv Exp Med Biol ; 1074: 289-295, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29721955

4.

Pyruvate kinase and aspartate-glutamate carrier distributions reveal key metabolic links between neurons and glia in retina.

Lindsay, Ken J; Du, Jianhai; Sloat, Stephanie R; Contreras, Laura; Linton, Jonathan D; Turner, Sally J; Sadilek, Martin; Satrústegui, Jorgina; Hurley, James B.

Proc Natl Acad Sci U S A ; 111(43): 15579-84, 2014 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-25313047

5.

Cytosolic reducing power preserves glutamate in retina.

Du, Jianhai; Cleghorn, Whitney; Contreras, Laura; Linton, Jonathan D; Chan, Guy C-K; Chertov, Andrei O; Saheki, Takeyori; Govindaraju, Viren; Sadilek, Martin; Satrústegui, Jorgina; Hurley, James B.

Proc Natl Acad Sci U S A ; 110(46): 18501-6, 2013 Nov 12.

Artigo em Inglês | MEDLINE | ID: mdl-24127593

6.

Na(V)1.1 channels are critical for intercellular communication in the suprachiasmatic nucleus and for normal circadian rhythms.

Han, Sung; Yu, Frank H; Schwartz, Michael D; Linton, Jonathan D; Bosma, Martha M; Hurley, James B; Catterall, William A; de la Iglesia, Horacio O.

Proc Natl Acad Sci U S A ; 109(6): E368-77, 2012 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-22223655

7.

Research: All journals need to correct errors.

Linton, Jonathan D.

Nature ; 504(7478): 33, 2013 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-24305141

8.

Flow of energy in the outer retina in darkness and in light.

Linton, Jonathan D; Holzhausen, Lars C; Babai, Norbert; Song, Hongman; Miyagishima, Kiyoharu J; Stearns, George W; Lindsay, Ken; Wei, Junhua; Chertov, Andrei O; Peters, Theo A; Caffe, Romeo; Pluk, Helma; Seeliger, Mathias W; Tanimoto, Naoyuki; Fong, Kimberly; Bolton, Laura; Kuok, Denise L T; Sweet, Ian R; Bartoletti, Theodore M; Radu, Roxana A; Travis, Gabriel H; Zagotta, Willam N; Townes-Anderson, Ellen; Parker, Ed; Van der Zee, Catharina E E M; Sampath, Alapakkam P; Sokolov, Maxim; Thoreson, Wallace B; Hurley, James B.

Proc Natl Acad Sci U S A ; 107(19): 8599-604, 2010 May 11.

Artigo em Inglês | MEDLINE | ID: mdl-20445106

9.

Roles of glucose in photoreceptor survival.

Chertov, Andrei O; Holzhausen, Lars; Kuok, Iok Teng; Couron, Drew; Parker, Ed; Linton, Jonathan D; Sadilek, Martin; Sweet, Ian R; Hurley, James B.

J Biol Chem ; 286(40): 34700-11, 2011 Oct 07.

Artigo em Inglês | MEDLINE | ID: mdl-21840997

10.

Understanding and Managing the Biotechnology Valley of Death.

Linton, Jonathan D; Xu, Wei.

Trends Biotechnol ; 39(2): 107-110, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-32718779

11.

Building the Next Generation of Humanized Hemato-Lymphoid System Mice.

Martinov, Tijana; McKenna, Kelly M; Tan, Wei Hong; Collins, Emily J; Kehret, Allie R; Linton, Jonathan D; Olsen, Tayla M; Shobaki, Nour; Rongvaux, Anthony.

Front Immunol ; 12: 643852, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33692812

12.

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice.

Tsantilas, Kristine A; Cleghorn, Whitney M; Bisbach, Celia M; Whitson, Jeremy A; Hass, Daniel T; Robbings, Brian M; Sadilek, Martin; Linton, Jonathan D; Rountree, Austin M; Valencia, Ana P; Sweetwyne, Mariya T; Campbell, Matthew D; Zhang, Huiliang; Jankowski, Connor S R; Sweet, Ian R; Marcinek, David J; Rabinovitch, Peter S; Hurley, James B.

Invest Ophthalmol Vis Sci ; 62(14): 20, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34797906

13.

Biotechnology Patenting in the BRICS Countries: Strategies and Dynamics.

Streltsova, Ekaterina; Linton, Jonathan D.

Trends Biotechnol ; 36(7): 642-645, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29310840

14.

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability.

Rajala, Ammaji; Wang, Yuhong; Brush, Richard S; Tsantilas, Kristine; Jankowski, Connor S R; Lindsay, Ken J; Linton, Jonathan D; Hurley, James B; Anderson, Robert E; Rajala, Raju V S.

Cell Death Dis ; 9(2): 240, 2018 02 14.

Artigo em Inglês | MEDLINE | ID: mdl-29445082

15.

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.

Kanow, Mark A; Giarmarco, Michelle M; Jankowski, Connor Sr; Tsantilas, Kristine; Engel, Abbi L; Du, Jianhai; Linton, Jonathan D; Farnsworth, Christopher C; Sloat, Stephanie R; Rountree, Austin; Sweet, Ian R; Lindsay, Ken J; Parker, Edward D; Brockerhoff, Susan E; Sadilek, Martin; Chao, Jennifer R; Hurley, James B.

Elife ; 62017 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-28901286

16.

Probing Metabolism in the Intact Retina Using Stable Isotope Tracers.

Du, Jianhai; Linton, Jonathan D; Hurley, James B.

Methods Enzymol ; 561: 149-70, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26358904

17.

Improving value assessment of high-risk, high-reward biotechnology research: the role of 'thick tails'.

Casault, Sébastien; Groen, Aard J; Linton, Jonathan D.

N Biotechnol ; 31(2): 172-8, 2014 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-24361531

18.

Policy planning under uncertainty: efficient starting populations for simulation-optimization methods applied to municipal solid waste management.

Huang, Gordon H; Linton, Jonathan D; Yeomans, Julian Scott; Yoogalingam, Reena.

J Environ Manage ; 77(1): 22-34, 2005 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15949891

19.

From bench to business.

Linton, Jonathan D; Walsh, Steven T.

Nat Mater ; 2(5): 287-9, 2003 May.

Artigo em Inglês | MEDLINE | ID: mdl-12728227

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